| Neglatu | Uplifted revenants with an affinity for their former kind. | As uplifted clan | Agah | Cannot use the blood bond | Onyx Path blog |
| Parliamentarians | Tedious, browbeating Carthians who religiously adhere to the party line. | Animalism, Auspex, Celerity, Majesty | Bloodline Merits | Cap Social dice pools by Humanity when conventional order is broken | NH-SB 33 |
| Penumbrae | Acolyte psychonauts who read visions in the skein of the Blood. | Auspex, Celerity, Crúac, Vigor | Crúac Rites | Dots of Crúac deepen states of torpor | NH-SB 37 |
| Scions of the First City | Urban mystics who see through the eyes of their city. | Animalism, Auspex, Obfuscate, Resilience | Bloodline Devotions | Cap all dice pools by Humanity outside your city | NH-SB 41 |
| Daeva Bloodlines | | | | | |
| Jharana | Obsessive technomystics chosen from those touched by the God-Machine. | Auspex, Dead Signal, Celerity, Vigor | Bloodline Discipline | Risk Persistent Obsession from the Wanton Curse | NH-SB 20 |
| Lidérc | Passionate lovers who drink from the ardor they incite. | Celerity, Majesty, Obfuscate, Vigor | Siphon Devotions | The Wanton Curse also disrupts Touchstones | NH-SB 24 |
| Vilseduire | Narcissistic rebels who revel in glamorous transgression | Majesty, Nightmare, Obfuscate, Resilience | None | Only one Touchstone, and risk detachment at lower Humanity | NH-SB 50 |
| Gangrel Bloodlines | | | | | |
| Kerberos | Self-reinventing social predators who excel at projecting the Beast. | Animalism, Majesty, Protean, Resilience | Hounds of Hell | Lose 10-again to oppose characters without the Predatory Aura | Onyx Path blog |
| Nosoi | Plague farmers who cultivate blood-borne disease in the herd. | Dominate, Obfuscate, Protean, Resilience | Bloodline Devotions | Imbibed Vitae untainted by your disease is capped nightly by Humanity | NH-SB 29 |
| Mekhet Bloodlines | | | | | |
| Ankou | Killers who keep the living separate from the dead for the greater good. | Auspex, Celerity, Obfuscate, Vigor | None | Must roll Humanity to recover Willpower from Mask | NH-SB 12 |
| Icelus | Manipulators disguised as hypnotherapists plumbing the collective unconscious. | Auspex, Dominate, Obfuscate, Resilience | Psychognosis Merit | Detachment inflicts a Mesmerized state | NH-SB 15 |
| Khaibit | An ancient line of soldiers who fight darkness by embracing it. | Auspex, Celerity, Obfuscate, Vigor | Obtenebration Devotions | Temporarily blinded by any light bright enough to inhibit normal vision | Onyx Path blog |
| Morbus | Outcast plague angels who feed on diseased vessels. | Auspex, Celerity, Cachexy, Obfuscate | Bloodline Discipline | Can’t feed on the living free of disease | DEC 94 |
| Nosferatu Bloodlines | | | | | |
| Vilseduire | Narcissistic rebels who revel in glamorous transgression | Majesty, Nightmare, Obfuscate, Resilience | None | Only one Touchstone, and risk detachment at lower Humanity | NH-SB 50 |
| Ventrue Bloodlines | | | | | |
| Bron | Knights errant and bravos who live by blood, quest, and oath. | Animalism, Crochan, Dominate, Resilience | Bloodline Discipline | Touchstones are vulnerable to detaching and changing by the whims of fate | DE2 117 |
| Icelus | Manipulators disguised as hypnotherapists plumbing the collective unconscious. | Auspex, Dominate, Obfuscate, Resilience | Psychognosis Merit | Detachment inflicts a Mesmerized state | NH-SB 15 |
| Vardyvle | Jealous dreamers who yearn for what they are not and lose themselves in others’ lives. | Dominate, Obfuscate, Protean, Resilience | Shapeshifting Devotion | Feeding from those living your dreams risks False Memories | NH-SB 45 |